Please continue to consolidate purchasing of all other Millipore Corporation products through Fisher Scientific to enjoy streamlined ordering and free shipping.įor questions regarding ordering from Millipore Corporation ordering, please contact Customer Service. The following Millipore Corporation products are now available through the PantherExpress System using the Millipore Corporation punchout:Īll service agreements for Millipore equipment should be placed directly with Millipore using the non-catalog form in the PantherExpress System.Īll Millipore Corporation orders have a flat $32 shipping fee. For questions regarding your Millipore Corporation order, please contact the supplier contact listed below.Īll other Millipore products can be purchased through the Fisher Scientific punchout in the PantherExpress System. At this time, certain products are available through Millipore Corporation while other products are available through EMD Millipore Corporation (EMD Chemicals).ĮMD Chemical products are still sold separately using the existing EMD MILLIPORE CORP (EMD Chemicals) punchout. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.In late 2011, EMD Chemicals merged with Millipore Corporation to form a company called EMD Millipore Corporation. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.Click here for Enduser Declaration (EUD) Form. This legislation obliges MilliporeSigma to request certain information about you and the establishment where the GMOs are being handled. Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This product contains genetically modified organisms (GMO).Cells are negative for mycoplasma contamination.Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services.Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services. Each vial contains ≥ 1X10 6 viable cells.For information regarding any other use, please contact Information The MILLIPLEX MAP Rat Cytokine/Chemokine Magnetic Bead Panel (RECYTMAG-65K) enables you to focus on the therapeutic potential of cytokines, as well as the modulation of cytokine expression. This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. (1997) J Immunol 158(6): 2723-2730.ĭC2.4 dendritic cell line can be used to study dendritic cell biology and immune response. These difficulties have limited the studies of dendritic cells.ġ. Despite their distribution in most tissues, DC are present at low numbers in vivo and are difficult to maintain in vitro. DCs also express Toll-like receptors and help regulate the innate immune responses. First described in 1973 (1), one of the primary functions of DCs is to phagocytose foreign pathogens and present the processed antigens to naïve T cells to regulate adaptive immune responses. We collaborate with customers to solve the. DC2.4 exhibits characteristic features of dendritic cells including cell morphology and the expression of dendritic cell-specific markers and the ability to phagocytose and present exogenous antigens on both MHC class I and class II molecules (2).ĭendritic cells (DC) are the antigen presenting cells of the immune system and are found in most tissues, particularly those that are in contact with the external environment (e.g., skin and the inner linings of the nose, lungs, stomach and intestine). The life science business of Merck KGaA, Darmstadt, Germany, operates as MilliporeSigma in the US and Canada. Key Specifications Table Key ApplicationsĭC2.4 are immortalized murine dendritic cells created by transducing bone marrow isolates of C57BL/6 mice with retrovirus vectors expressing murine granulocyte-macrophage CSF (GM-CSF) and the myc and raf oncogenes (2).
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